4fc7: Difference between revisions
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{{STRUCTURE_4fc7| PDB=4fc7 | SCENE= }} | {{STRUCTURE_4fc7| PDB=4fc7 | SCENE= }} | ||
===Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR=== | ===Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR=== | ||
{{ABSTRACT_PUBMED_22745130}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DECR2_HUMAN DECR2_HUMAN]] Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022745130</ref><references group="xtra"/> | <ref group="xtra">PMID:022745130</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hua, T.]] | [[Category: Hua, T.]] | ||
Revision as of 11:01, 24 July 2013
Studies on DCR shed new light on peroxisomal beta-oxidation: Crystal structure of the ternary complex of pDCR
Template:ABSTRACT PUBMED 22745130
Function
[DECR2_HUMAN] Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
About this Structure
4fc7 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Hua T, Wu D, Ding W, Wang J, Shaw N, Liu ZJ. Studies on human 2, 4 dienoyl CoA reductase (DCR) sheds new light on peroxisomal beta-oxidation of unsaturated fatty acids. J Biol Chem. 2012 Jun 28. PMID:22745130 doi:10.1074/jbc.M112.385351
