4b0q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Lead Generation of BACE1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold===

~~The entry 4b0q~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Pendrill, R~~.~~, Kolmodin, K~~.~~, Johansson, P~~.~~, Plobeck, N~~.

==About this Structure==

[[4b0q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0Q OCA].

~~Description~~: Lead ~~Generation of BACE1 Inhibitors by Coupling Non~~-~~amidine New Warheads to a Known Binding Scaffold~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Memapsin 2]]

[[Category: Johansson, P.]]

[[Category: Kolmodin, K.]]

[[Category: Pendrill, R.]]

[[Category: Plobeck, N.]]

[[Category: Bace1 inhibitor]]

[[Category: Hydrolase]]

[[Category: Lead generation]]

[[Category: Structure-based drug design]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4b0q|  PDB=4b0q  |  SCENE=  }}
+===Lead Generation of BACE1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold===
-The entry 4b0q is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Pendrill, R., Kolmodin, K., Johansson, P., Plobeck, N.
+==About this Structure==
+[[4b0q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B0Q OCA].
-Description: Lead Generation of BACE1 Inhibitors by Coupling Non-amidine New Warheads to a Known Binding Scaffold
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Johansson, P.]]
+[[Category: Kolmodin, K.]]
+[[Category: Pendrill, R.]]
+[[Category: Plobeck, N.]]
+[[Category: Bace1 inhibitor]]
+[[Category: Hydrolase]]
+[[Category: Lead generation]]
+[[Category: Structure-based drug design]]