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| <StructureSection load='1v04' size='400' side='right' caption='PON1 - looking down 6-bladed propellers, Ca+2 and 2HQ' scene='Journal:JMB:2/Opening/4'> | | <StructureSection load='1v04' size='400' side='right' caption='PON1 - looking down 6-bladed propellers, Ca+2 and 2HQ' scene='Journal:JMB:2/Opening/4'> |
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| While , as expected, there are some key differences. The side-chain of V346 within the active site pocket is <scene name='Journal:JMB:2/Scene_4_2/1'>rotated relative to the pH 4.5 structure</scene>, and the side-chains of F347 and H348 in the active site's 'second shell' <scene name='Journal:JMB:2/Scene_5_2/1'>adopted completely different rotamers</scene>.
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| We experimentally solved two critical new PON1 structures. Previously solved in <scene name='Journal:JMB:2/Scene_1_2/3'>non-physiological conditions of pH 4.5</scene>, we have solved PON1 in <scene name='Journal:JMB:2/Scene_2_2/2'>physiological conditions of pH 6.5</scene>. While <scene name='Journal:JMB:2/Scene_3_2/1'>generally similar</scene>, as expected, there are some key differences. The side-chain of V346 within the active site pocket is <scene name='Journal:JMB:2/Scene_4_2/1'>rotated relative to the pH 4.5 structure</scene>, and the side-chains of F347 and H348 in the active site's 'second shell' <scene name='Journal:JMB:2/Scene_5_2/1'>adopted completely different rotamers</scene>.
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| =<p dir='rtl'>השפעת שינוי חומציות הסביבה על מבנה תלת מימדי של חלבון</p>= | | =<p dir='rtl'>השפעת שינוי חומציות הסביבה על מבנה תלת מימדי של חלבון</p>= |
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