Allosteric modulation of H-Ras GTPase: Difference between revisions

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{{STRUCTURE_3k8y|  PDB=3k8y  |  SCENE= | CAPTION=H-Ras GTPase activating protein, [[3k8y]]}}  
{{STRUCTURE_3k8y|  PDB=3k8y  |  SCENE= | CAPTION=H-Ras GTPase complex with GNP, Ca+2, Mg+2 and acetate ions, [[3k8y]]}}  


'''H-Ras''' is a small monomeric GTPase protein that is found inside of cells.  It helps regulate cell division in cells through signal transduction pathways such as the mitogen activated protein kinase (MAPK) pathway.  H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II.  Switch I is regions 30-40, Thymine 35 plays an important role in switch I region because it will bind to the magnesium ion and switch II is regions 60-76, Glycine 60 plays an important role for switch II region.  Both of these switches depend on the γ-phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it binds to a GTP molecule turning both switch regions “on”.  This pathway also involves GTPase activating protein, which catalyzes the hydrolysis of the GTP molecule that is bound to  Ras causing the switches to turn “off”.  Ras was first discovered in a retrovirus which was known to cause saracoma in rats hence the name "ras" "rat saracoma".   
'''H-Ras''' is a small monomeric GTPase protein that is found inside of cells.  It helps regulate cell division in cells through signal transduction pathways such as the mitogen activated protein kinase (MAPK) pathway.  H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II.  Switch I is regions 30-40, Thymine 35 plays an important role in switch I region because it will bind to the magnesium ion and switch II is regions 60-76, Glycine 60 plays an important role for switch II region.  Both of these switches depend on the γ-phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it binds to a GTP molecule turning both switch regions “on”.  This pathway also involves GTPase activating protein, which catalyzes the hydrolysis of the GTP molecule that is bound to  Ras causing the switches to turn “off”.  Ras was first discovered in a retrovirus which was known to cause saracoma in rats hence the name "ras" "rat saracoma".   
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