176d: Difference between revisions
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'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA''' | {{Structure | ||
|PDB= 176d |SIZE=350|CAPTION= <scene name='initialview01'>176d</scene> | |||
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'''NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
176D is a [ | 176D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=176D OCA]. | ||
==Reference== | ==Reference== | ||
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http:// | NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7519361 7519361] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brown, S C.]] | [[Category: Brown, S C.]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:50:18 2008'' | ||
Revision as of 07:50, 20 March 2008
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NMR SOLUTION STRUCTURE OF A PEPTIDE NUCLEIC ACID COMPLEXED WITH RNA
Overview
Peptide nucleic acids (PNA) incorporating nucleic acid bases into an achiral polyamide backbone bind to DNA in a sequence-dependent manner. The structure of a PNA-ribonucleic acid (RNA) complex was determined with nuclear magnetic resonance methods. A hexameric PNA formed a 1:1 complex with a complementary RNA that is an antiparallel, right-handed double helix with Watson-Crick base pairing similar to the "A" form structure of RNA duplexes. The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
About this Structure
176D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR solution structure of a peptide nucleic acid complexed with RNA., Brown SC, Thomson SA, Veal JM, Davis DG, Science. 1994 Aug 5;265(5173):777-80. PMID:7519361
Page seeded by OCA on Thu Mar 20 09:50:18 2008
