4f0a: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4f0a| PDB=4f0a | SCENE= }} | {{STRUCTURE_4f0a| PDB=4f0a | SCENE= }} | ||
===Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8=== | ===Crystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8=== | ||
{{ABSTRACT_PUBMED_22653731}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FZD8_MOUSE FZD8_MOUSE]] Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.<ref>PMID:10395542</ref> <ref>PMID:10097073</ref> <ref>PMID:15454084</ref> <ref>PMID:16543246</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 10: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022653731</ref><references group="xtra"/> | <ref group="xtra">PMID:022653731</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
