4fx8: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4fx8|  PDB=4fx8  |  SCENE=  }}
===Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP===
{{ABSTRACT_PUBMED_23030629}}


The entry 4fx8 is ON HOLD  until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]


Authors: Fedorov, A.A., Fedorov, E.V., Desai, B., Gerlt, J.A., Almo, S.C.
==About this Structure==
[[4fx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._delta_h Methanothermobacter thermautotrophicus str. delta h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FX8 OCA].  


Description: Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
==Reference==
<ref group="xtra">PMID:023030629</ref><references group="xtra"/><references/>
[[Category: Methanothermobacter thermautotrophicus str. delta h]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Almo, S C.]]
[[Category: Desai, B.]]
[[Category: Fedorov, A A.]]
[[Category: Fedorov, E V.]]
[[Category: Gerlt, J A.]]
[[Category: Inhibitor bmp]]
[[Category: Lyase-lyase inhibitor complex]]
[[Category: Tim barrel]]

Revision as of 13:40, 19 June 2013

Template:STRUCTURE 4fx8

Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Template:ABSTRACT PUBMED 23030629

Function

[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]

About this Structure

4fx8 is a 2 chain structure with sequence from Methanothermobacter thermautotrophicus str. delta h. Full crystallographic information is available from OCA.

Reference

  1. Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, Richard JP, Almo SC, Gerlt JA. Conformational Changes in Orotidine 5'-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5'-Phosphate Group Activates the Enzyme. Biochemistry. 2012 Oct 17. PMID:23030629 doi:10.1021/bi301188k

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