1a4f: Difference between revisions
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[[Image:1a4f.gif|left|200px]] | [[Image:1a4f.gif|left|200px]] | ||
'''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | {{Structure | ||
|PDB= 1a4f |SIZE=350|CAPTION= <scene name='initialview01'>1a4f</scene>, resolution 2.0Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=OXY:OXYGEN MOLECULE'>OXY</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1A4F is a [ | 1A4F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Anser_indicus Anser indicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4F OCA]. | ||
==Reference== | ==Reference== | ||
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:[http:// | The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8568892 8568892] | ||
[[Category: Anser indicus]] | [[Category: Anser indicus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: respiratory protein]] | [[Category: respiratory protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:52:47 2008'' | ||
Revision as of 07:52, 20 March 2008
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| 1a4f, resolution 2.0Å | |||||||||||||
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| Ligands: | HEM and OXY | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
BAR-HEADED GOOSE HEMOGLOBIN (OXY FORM)
Overview
We have determined the crystal structure of bar-headed goose haemoglobin in the oxy form to a resolution of 2.0 A. The R-factor of the model is 19.8%. The structure is similar to human HbA, but contacts between the subunits show slightly altered packing of the tetramer. Bar-headed goose blood shows a greatly elevated oxygen affinity compared to closely related species of geese. This is apparently due to a single proline to alanine mutation at the alpha 1 beta 1 interface which destabilises the T state of the protein. The beta chain N and C termini are well-localized, and together with other neighbouring basic groups they form a strongly positively charged groove at the entrance to the central cavity around the molecular dyad. The well-ordered conformation and the three-dimensional distribution of positive charges clearly indicate this area to be the inositol pentaphosphate binding site of bird haemoglobins.
About this Structure
1A4F is a Protein complex structure of sequences from Anser indicus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)., Zhang J, Hua Z, Tame JR, Lu G, Zhang R, Gu X, J Mol Biol. 1996 Jan 26;255(3):484-93. PMID:8568892
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