1a4v: Difference between revisions
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'''ALPHA-LACTALBUMIN''' | {{Structure | ||
|PDB= 1a4v |SIZE=350|CAPTION= <scene name='initialview01'>1a4v</scene>, resolution 1.8Å | |||
|SITE= <scene name='pdbsite=CB1:Ca+Binding+Site+In+The+Ca-Binding-Elbow+Region+Is+Referr+...'>CB1</scene> and <scene name='pdbsite=CB2:This+Is+The+Secondary+Ca+Binding+Site.+At+This+Site+The+...'>CB2</scene> | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22] | |||
|GENE= | |||
}} | |||
'''ALPHA-LACTALBUMIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1A4V is a [ | 1A4V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4V OCA]. | ||
==Reference== | ==Reference== | ||
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:[http:// | Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9537992 9537992] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Lactose synthase]] | [[Category: Lactose synthase]] | ||
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[[Category: lactose synthase]] | [[Category: lactose synthase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:52:57 2008'' | ||
Revision as of 07:52, 20 March 2008
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| 1a4v, resolution 1.8Å | |||||||||||||
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| Sites: | CB1 and CB2 | ||||||||||||
| Ligands: | CA | ||||||||||||
| Activity: | Lactose synthase, with EC number 2.4.1.22 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
ALPHA-LACTALBUMIN
Overview
The high-resolution X-ray crystal structure of human alpha-lactalbumin (at 1.8 A) in the presence of an elevated level of calcium reveals a new secondary calcium binding site, 7.9 A away from the primary calcium binding site known in all alpha-lactalbumin structures so far. The new calcium binding site is different from the zinc and sulfate binding sites [Ren, J., et al. (1993) J. Biol. Chem. 268, 19292-19298] but shares common features with the manganese binding site as described by Gerkin [Gerkin, T. A. (1984) Biochemistry 23, 4688-4697]. The proximity of the manganese and calcium binding region and the location of the functional site on one side of the charged surface of the alpha-lactalbumin molecule suggest that these binding sites might play a role in the formation of the lactose synthase complex.
About this Structure
1A4V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:9537992
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