3p9a: Difference between revisions

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[[Image:3p9a.png|left|200px]]
==An atomic view of the nonameric small terminase subunit of Bacteriophage P22==
<StructureSection load='3p9a' size='340' side='right' caption='[[3p9a]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3p9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P9A FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10754 Enterobacteria phage P22])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p9a RCSB], [http://www.ebi.ac.uk/pdbsum/3p9a PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Packaging of viral genomes into empty procapsids is powered by a large DNA-packaging motor. In most viruses, this machine is composed of a large (L) and a small (S) terminase subunit complexed with a dodecamer of portal protein. Here we describe the 1.75 A crystal structure of the bacteriophage P22 S-terminase in a nonameric conformation. The structure presents a central channel approximately 23 A in diameter, sufficiently large to accommodate hydrated B-DNA. The last 23 residues of S-terminase are essential for binding to DNA and assembly to L-terminase. Upon binding to its own DNA, S-terminase functions as a specific activator of L-terminase ATPase activity. The DNA-dependent stimulation of ATPase activity thus rationalizes the exclusive specificity of genome-packaging motors for viral DNA in the crowd of host DNA, ensuring fidelity of packaging and avoiding wasteful ATP hydrolysis. This posits a model for DNA-dependent activation of genome-packaging motors of general interest in virology.


{{STRUCTURE_3p9a|  PDB=3p9a  |  SCENE=  }}
Small Terminase Couples Viral DNA Binding to Genome-Packaging ATPase Activity.,Roy A, Bhardwaj A, Datta P, Lander GC, Cingolani G Structure. 2012 Jul 3. PMID:22771211<ref>PMID:22771211</ref>


===An atomic view of the nonameric small terminase subunit of Bacteriophage P22===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22771211}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3p9a]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9A OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:022771211</ref><references group="xtra"/>
[[Category: Enterobacteria phage p22]]
[[Category: Enterobacteria phage p22]]
[[Category: Bhardwaj, A.]]
[[Category: Bhardwaj, A.]]
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