1a7h: Difference between revisions
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[[Image:1a7h.gif|left|200px]] | [[Image:1a7h.gif|left|200px]] | ||
'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN''' | {{Structure | ||
|PDB= 1a7h |SIZE=350|CAPTION= <scene name='initialview01'>1a7h</scene>, resolution 2.56Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= CRYGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus]) | |||
}} | |||
'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1A7H is a [ | 1A7H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA]. | ||
==Reference== | ==Reference== | ||
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:[http:// | The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9681865 9681865] | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: multigene family]] | [[Category: multigene family]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:00 2008'' | ||
Revision as of 07:54, 20 March 2008
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| 1a7h, resolution 2.56Å | |||||||||||||
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| Gene: | CRYGS (Bos taurus) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
GAMMA S CRYSTALLIN C-TERMINAL DOMAIN
Overview
The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
About this Structure
1A7H is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis., Basak AK, Kroone RC, Lubsen NH, Naylor CE, Jaenicke R, Slingsby C, Protein Eng. 1998 May;11(5):337-44. PMID:9681865
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