1a85: Difference between revisions

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[[Image:1a85.gif|left|200px]]<br /><applet load="1a85" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1a85.gif|left|200px]]
caption="1a85, resolution 2.0&Aring;" />
 
'''MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR'''<br />
{{Structure
|PDB= 1a85 |SIZE=350|CAPTION= <scene name='initialview01'>1a85</scene>, resolution 2.0&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=HMI:2-HYDROXYCARBAMOYL-4-METHYL-PENTANOIC ACID'>HMI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34]
|GENE=
}}
 
'''MMP8 WITH MALONIC AND ASPARAGINE BASED INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1A85 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=HMI:'>HMI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A85 OCA].  
1A85 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A85 OCA].  


==Reference==
==Reference==
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data., Brandstetter H, Engh RA, Von Roedern EG, Moroder L, Huber R, Bode W, Grams F, Protein Sci. 1998 Jun;7(6):1303-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9655333 9655333]
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data., Brandstetter H, Engh RA, Von Roedern EG, Moroder L, Huber R, Bode W, Grams F, Protein Sci. 1998 Jun;7(6):1303-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9655333 9655333]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]
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[[Category: mmp8]]
[[Category: mmp8]]


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