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'''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES''' | {{Structure | ||
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'''UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1AFX is a [ | 1AFX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFX OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:[http:// | Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10074938 10074938] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Butcher, S E.]] | [[Category: Butcher, S E.]] | ||
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[[Category: tetraloop]] | [[Category: tetraloop]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:56:59 2008'' | ||
Revision as of 07:57, 20 March 2008
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UGAA EUKARYOTIC RIBOSOMAL RNA TETRALOOP, NMR, 13 STRUCTURES
Overview
The hairpin ribozyme is a small catalytic RNA with a unique two-domain structure. Here we present the solution structure of the loop B domain of the hairpin ribozyme, which contains most of the catalytically essential nucleotides. The 38-nucleotide domain contains a 16-nucleotide internal loop that forms one of the largest non-Watson-Crick segments of base pairing thus far determined by either NMR or crystallography. Since the solution structure of the smaller loop A domain has been previously solved, an NMR structure-based model of the 22,000 Mr hairpin ribozyme-substrate open complex emerges by joining the two domain structures. Strikingly, catalytically essential functional groups for the loop B domain are concentrated within an expanded minor groove, presenting a clear docking surface for the loop A domain.
About this Structure
1AFX is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Solution structure of the loop B domain from the hairpin ribozyme., Butcher SE, Allain FH, Feigon J, Nat Struct Biol. 1999 Mar;6(3):212-6. PMID:10074938
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