1ai3: Difference between revisions

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[[Image:1ai3.gif|left|200px]]~~<br /><applet load~~="1ai3~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1ai3.gif|left|200px]]

~~caption="~~1ai3, resolution 1.9Å" />

'''ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES'''~~<br />~~

{{Structure

|PDB= 1ai3 |SIZE=350|CAPTION= <scene name='initialview01'>1ai3</scene>, resolution 1.9Å

|SITE=

|LIGAND= <scene name='pdbligand=NDO:NICOTINAMIDE-(6-DEAMINO-6-HYDROXY-ADENINE)-DINUCLEOTIDE+PHOSPHATE'>NDO</scene> and <scene name='pdbligand=ITM:ISOCITRIC ACID-MAGNESIUM COMPLEX'>ITM</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42]

|GENE=

}}

'''ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES'''

==Overview==

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==About this Structure==

1AI3 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli~~] with <scene name='pdbligand=NDO:'>NDO</scene> and <scene name='pdbligand=ITM:'>ITM</scene> as [http://en.wikipedia.org/wiki/ligands ligands~~]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AI3 OCA].

1AI3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AI3 OCA].

==Reference==

Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences., Mesecar AD, Stoddard BL, Koshland DE Jr, Science. 1997 Jul 11;277(5323):202-6. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~9211842 9211842]

Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences., Mesecar AD, Stoddard BL, Koshland DE Jr, Science. 1997 Jul 11;277(5323):202-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9211842 9211842]

[[Category: Escherichia coli]]

[[Category: Isocitrate dehydrogenase (NADP(+))]]

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[[Category: phosphorylation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 11~~:44:43 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:57:51 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ai3.gif|left|200px]]<br /><applet load="1ai3" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ai3.gif|left|200px]]
-caption="1ai3, resolution 1.9&Aring;" />
-'''ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES'''<br />
+ {{Structure
+|PDB= 1ai3 |SIZE=350|CAPTION= <scene name='initialview01'>1ai3</scene>, resolution 1.9&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NDO:NICOTINAMIDE-(6-DEAMINO-6-HYDROXY-ADENINE)-DINUCLEOTIDE+PHOSPHATE'>NDO</scene> and <scene name='pdbligand=ITM:ISOCITRIC ACID-MAGNESIUM COMPLEX'>ITM</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42]
+|GENE=
+}}
+'''ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-AI3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NDO:'>NDO</scene> and <scene name='pdbligand=ITM:'>ITM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AI3 OCA].
+AI3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AI3 OCA].
 ==Reference==
-Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences., Mesecar AD, Stoddard BL, Koshland DE Jr, Science. 1997 Jul 11;277(5323):202-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9211842 9211842]
+Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences., Mesecar AD, Stoddard BL, Koshland DE Jr, Science. 1997 Jul 11;277(5323):202-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9211842 9211842]
 [[Category: Escherichia coli]]
 [[Category: Isocitrate dehydrogenase (NADP(+))]]
@@ Line 24: / Line 33: @@
 [[Category: phosphorylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:44:43 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:57:51 2008''