1ajv: Difference between revisions

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[[Image:1ajv.jpg|left|200px]]<br /><applet load="1ajv" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ajv.jpg|left|200px]]
caption="1ajv, resolution 2.00&Aring;" />
 
'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''<br />
{{Structure
|PDB= 1ajv |SIZE=350|CAPTION= <scene name='initialview01'>1ajv</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=NMB:2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL'>NMB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= PROTEASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human immunodeficiency virus type 1 (isolate 12)])
}}
 
'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1AJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)] with <scene name='pdbligand=NMB:'>NMB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJV OCA].  
1AJV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJV OCA].  


==Reference==
==Reference==
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9083478 9083478]
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9083478 9083478]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
[[Category: Human immunodeficiency virus type 1 (isolate 12)]]
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[[Category: protease]]
[[Category: protease]]


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