1an5: Difference between revisions

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[[Image:1an5.gif|left|200px]]~~<br /><applet load~~="1an5~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1an5.gif|left|200px]]

~~caption="~~1an5, resolution 2.60Å" />

'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717'''~~<br />~~

{{Structure

|PDB= 1an5 |SIZE=350|CAPTION= <scene name='initialview01'>1an5</scene>, resolution 2.60Å

|SITE= <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>

|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]

|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])

}}

'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717'''

==Overview==

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==About this Structure==

1AN5 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN5 OCA].

1AN5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN5 OCA].

==Reference==

The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~9687366 9687366]

The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9687366 9687366]

[[Category: Escherichia coli]]

[[Category: Single protein]]

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[[Category: CB3]]

[[Category: PO4]]

[[Category: substrate ~~modules~~]]

[[Category: substrate module]]

[[Category: transferase (methyltransferase)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 11~~:46:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:59:49 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1an5.gif|left|200px]]<br /><applet load="1an5" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1an5.gif|left|200px]]
-caption="1an5, resolution 2.60&Aring;" />
-'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717'''<br />
+ {{Structure
+|PDB= 1an5 |SIZE=350|CAPTION= <scene name='initialview01'>1an5</scene>, resolution 2.60&Aring;
+|SITE= <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>
+|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC ACID'>CB3</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
+|GENE= THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+}}
+'''E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-AN5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=CB3:'>CB3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Known structural/functional Site: <scene name='pdbsite=ACT:Active+Site+Reactive+Thiol'>ACT</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN5 OCA].
+AN5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN5 OCA].
 ==Reference==
-The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9687366 9687366]
+The additivity of substrate fragments in enzyme-ligand binding., Stout TJ, Sage CR, Stroud RM, Structure. 1998 Jul 15;6(7):839-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9687366 9687366]
 [[Category: Escherichia coli]]
 [[Category: Single protein]]
@@ Line 19: / Line 28: @@
 [[Category: CB3]]
 [[Category: PO4]]
-[[Category: substrate modules]]
+[[Category: substrate module]]
 [[Category: transferase (methyltransferase)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:59:49 2008''