1awf: Difference between revisions

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[[Image:1awf.gif|left|200px]]<br /><applet load="1awf" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1awf.gif|left|200px]]
caption="1awf, resolution 2.2&Aring;" />
 
'''NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT'''<br />
{{Structure
|PDB= 1awf |SIZE=350|CAPTION= <scene name='initialview01'>1awf</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=NUL:Catalytic+Triad+Of+SER+Proteinases'>NUL</scene>
|LIGAND= <scene name='pdbligand=GR4:R3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-12,16-DIHYDROXY-14-HYDROXYMETHYL-4,10,13-TRIMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID IDOPYRANOSYL ESTER'>GR4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]
|GENE=
}}
 
'''NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1AWF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GR4:'>GR4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] Known structural/functional Site: <scene name='pdbsite=NUL:Catalytic+Triad+Of+SER+Proteinases'>NUL</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWF OCA].  
1AWF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWF OCA].  


==Reference==
==Reference==
Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies., Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW, Biochemistry. 1998 May 12;37(19):6645-57. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9578548 9578548]
Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies., Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW, Biochemistry. 1998 May 12;37(19):6645-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9578548 9578548]
[[Category: Hirudo medicinalis]]
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: trypsin like proteinase]]
[[Category: trypsin like proteinase]]


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