1b0f: Difference between revisions

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[[Image:1b0f.gif|left|200px]]<br /><applet load="1b0f" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1b0f.gif|left|200px]]
caption="1b0f, resolution 3.00&Aring;" />
 
'''CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146'''<br />
{{Structure
|PDB= 1b0f |SIZE=350|CAPTION= <scene name='initialview01'>1b0f</scene>, resolution 3.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SEI:1-{3-METHYL-2-[4-(MORPHOLINE-4-CARBONYL)-BENZOYLAMINO]-BUTYRYL}-PYRROLIDINE-2-CARBOXYLIC ACID (3,3,4,4,4-PENTAFLUORO-1-ISOPROPYL-2-OXO-BUTYL)-AMIDE'>SEI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE WITH MDL 101, 146'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1B0F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SEI:'>SEI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0F OCA].  
1B0F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B0F OCA].  


==Reference==
==Reference==
Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones., Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C, J Med Chem. 1998 Jul 2;41(14):2461-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9651152 9651152]
Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones., Cregge RJ, Durham SL, Farr RA, Gallion SL, Hare CM, Hoffman RV, Janusz MJ, Kim HO, Koehl JR, Mehdi S, Metz WA, Peet NP, Pelton JT, Schreuder HA, Sunder S, Tardif C, J Med Chem. 1998 Jul 2;41(14):2461-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9651152 9651152]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Leukocyte elastase]]
[[Category: Leukocyte elastase]]
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[[Category: Tardif, C.]]
[[Category: Tardif, C.]]
[[Category: SEI]]
[[Category: SEI]]
[[Category: fluoroethyl ketones]]
[[Category: fluoroethyl ketone]]
[[Category: serine protease]]
[[Category: serine protease]]


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