1b4b: Difference between revisions
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'''STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS''' | {{Structure | ||
|PDB= 1b4b |SIZE=350|CAPTION= <scene name='initialview01'>1b4b</scene>, resolution 2.2Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ARG:ARGININE'>ARG</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1B4B is a [ | 1B4B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4B OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the arginine repressor from Bacillus stearothermophilus., Ni J, Sakanyan V, Charlier D, Glansdorff N, Van Duyne GD, Nat Struct Biol. 1999 May;6(5):427-32. PMID:[http:// | Structure of the arginine repressor from Bacillus stearothermophilus., Ni J, Sakanyan V, Charlier D, Glansdorff N, Van Duyne GD, Nat Struct Biol. 1999 May;6(5):427-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10331868 10331868] | ||
[[Category: Geobacillus stearothermophilus]] | [[Category: Geobacillus stearothermophilus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: repressor]] | [[Category: repressor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:06:03 2008'' | ||
Revision as of 08:06, 20 March 2008
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| 1b4b, resolution 2.2Å | |||||||||||||
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| Ligands: | ARG | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS
Overview
The arginine repressor (ArgR) is a hexameric DNA-binding protein that plays a multifunctional role in the bacterial cell. Here, we present the 2.5 A structure of apo-ArgR from Bacillus stearothermophilus and the 2.2 A structure of the hexameric ArgR oligomerization domain with bound arginine. This first view of intact ArgR reveals an approximately 32-symmetric hexamer of identical subunits, with six DNA-binding domains surrounding a central oligomeric core. The difference in quaternary organization of subunits in the arginine-bound and apo forms provides a possible explanation for poor operator binding by apo-ArgR and for high affinity binding in the presence of arginine.
About this Structure
1B4B is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
Structure of the arginine repressor from Bacillus stearothermophilus., Ni J, Sakanyan V, Charlier D, Glansdorff N, Van Duyne GD, Nat Struct Biol. 1999 May;6(5):427-32. PMID:10331868
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