1b4y: Difference between revisions
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[[Image:1b4y.gif|left|200px]] | [[Image:1b4y.gif|left|200px]] | ||
'''STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.''' | {{Structure | ||
|PDB= 1b4y |SIZE=350|CAPTION= <scene name='initialview01'>1b4y</scene> | |||
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'''STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1B4Y is a [ | 1B4Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA]. | ||
==Reference== | ==Reference== | ||
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:[http:// | Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10467098 10467098] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Boom, J H.Van.]] | [[Category: Boom, J H.Van.]] | ||
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[[Category: triple helix]] | [[Category: triple helix]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:06:20 2008'' | ||
Revision as of 08:06, 20 March 2008
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STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.
Overview
H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides.
About this Structure
1B4Y is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098
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