1b6k: Difference between revisions

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[[Image:1b6k.jpg|left|200px]]<br /><applet load="1b6k" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1b6k.jpg|left|200px]]
caption="1b6k, resolution 1.85&Aring;" />
 
'''HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5'''<br />
{{Structure
|PDB= 1b6k |SIZE=350|CAPTION= <scene name='initialview01'>1b6k</scene>, resolution 1.85&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=PI5:N-[3-(8-SEC-BUTYL-7,10-DIOXO-2-OXA-6,9-DIAZA-BICYCLO[11.2.2]HEPTADECA-1(16),13(17),14- TRIEN-11-YLAMINO)-2-HYDROXY-1-(4-HYDROXY-BENZYL)-PROPYL]-3-METHYL-2- (2-OXO-PYRROLIDIN-1-YL)-BUTYRAMIDE'>PI5</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1B6K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_arv2/sf2) Human immunodeficiency virus type 1 (isolate arv2/sf2)] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=PI5:'>PI5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6K OCA].  
1B6K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_arv2/sf2) Human immunodeficiency virus type 1 (isolate arv2/sf2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B6K OCA].  


==Reference==
==Reference==
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease., Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC, Fairlie DP, Biochemistry. 1999 Jun 22;38(25):7978-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10387041 10387041]
Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease., Martin JL, Begun J, Schindeler A, Wickramasinghe WA, Alewood D, Alewood PF, Bergman DA, Brinkworth RI, Abbenante G, March DR, Reid RC, Fairlie DP, Biochemistry. 1999 Jun 22;38(25):7978-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10387041 10387041]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus type 1 (isolate arv2/sf2)]]
[[Category: Human immunodeficiency virus type 1 (isolate arv2/sf2)]]
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[[Category: complex (acid proteinase/peptide)]]
[[Category: complex (acid proteinase/peptide)]]


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