1bau: Difference between revisions
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[[Image:1bau.gif|left|200px]] | [[Image:1bau.gif|left|200px]] | ||
'''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE''' | {{Structure | ||
|PDB= 1bau |SIZE=350|CAPTION= <scene name='initialview01'>1bau</scene> | |||
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'''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BAU is a [ | 1BAU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http:// | Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9628479 9628479] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Billeci, T M.]] | [[Category: Billeci, T M.]] | ||
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[[Category: rna]] | [[Category: rna]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:08:33 2008'' | ||
Revision as of 08:08, 20 March 2008
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NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE
Overview
Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.
About this Structure
1BAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479
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