1bfe: Difference between revisions
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'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95''' | {{Structure | ||
|PDB= 1bfe |SIZE=350|CAPTION= <scene name='initialview01'>1bfe</scene>, resolution 2.3Å | |||
|SITE= <scene name='pdbsite=PEP:Residues+Involved+In+The+Binding+Of+Four+C-Terminal+Resi+...'>PEP</scene> | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BFE is a [ | 1BFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:[http:// | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8674113 8674113] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein localization]] | [[Category: protein localization]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:10:16 2008'' | ||
Revision as of 08:10, 20 March 2008
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| 1bfe, resolution 2.3Å | |||||||||||||
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| Sites: | PEP | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Overview
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
About this Structure
1BFE is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113
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