3cj2: Difference between revisions
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Revision as of 17:47, 25 July 2012
Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments
Template:ABSTRACT PUBMED 18400495
About this Structure
3cj2 is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus subtype 1b. Full crystallographic information is available from OCA.
See Also
Reference
- Antonysamy SS, Aubol B, Blaney J, Browner MF, Giannetti AM, Harris SF, Hebert N, Hendle J, Hopkins S, Jefferson E, Kissinger C, Leveque V, Marciano D, McGee E, Najera I, Nolan B, Tomimoto M, Torres E, Wright T. Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2990-5. Epub 2008 Mar 22. PMID:18400495 doi:https://dx.doi.org/10.1016/j.bmcl.2008.03.056
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Hepatitis c virus subtype 1b
- RNA-directed RNA polymerase
- Kissinger, c.
- Apoptosis
- Atp-binding
- Capsid protein
- Drug discovery
- Endoplasmic reticulum
- Envelope protein
- Fragment based
- Fusion protein
- Glycoprotein
- Hcv ns5b
- Helicase
- Host-virus interaction
- Hydrolase
- Interferon antiviral system evasion
- Lipid droplet
- Lipoprotein
- Membrane
- Metal-binding
- Mitochondrion
- Multifunctional enzyme
- Nucleotide-binding
- Nucleotidyltransferase
- Nucleus
- Oncogene
- Palmitate
- Phosphoprotein
- Protease
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Secreted
- Serine protease
- Sh3-binding
- Thiol protease
- Transcription
- Transcription regulation
- Transferase
- Transmembrane
- Viral nucleoprotein
- Virion
