1bj8: Difference between revisions
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[[Image:1bj8.gif|left|200px]] | [[Image:1bj8.gif|left|200px]] | ||
'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE''' | {{Structure | ||
|PDB= 1bj8 |SIZE=350|CAPTION= <scene name='initialview01'>1bj8</scene> | |||
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|LIGAND= | |||
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'''THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BJ8 is a [ | 1BJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ8 OCA]. | ||
==Reference== | ==Reference== | ||
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:[http:// | The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10210178 10210178] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: receptor]] | [[Category: receptor]] | ||
[[Category: signal transducer of il-6 type | [[Category: signal transducer of il-6 type cytokine]] | ||
[[Category: third n-terminal domain]] | [[Category: third n-terminal domain]] | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:47 2008'' | ||
Revision as of 08:11, 20 March 2008
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THIRD N-TERMINAL DOMAIN OF GP130, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokine-receptor superfamily predicted to consist of six domains in its extracellular part. The second and third domain constitute the cytokine-binding module defined by a set of four conserved cysteines and a WSXWS motif, respectively. The three-dimensional structure of the carboxy-terminal domain of this region was determined by multidimensional NMR. The domain consists of seven beta-strands constituting a fibronectin type III-like topology. The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.
About this Structure
1BJ8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region., Kernebeck T, Pflanz S, Muller-Newen G, Kurapkat G, Scheek RM, Dijkstra K, Heinrich PC, Wollmer A, Grzesiek S, Grotzinger J, Protein Sci. 1999 Jan;8(1):5-12. PMID:10210178
Page seeded by OCA on Thu Mar 20 10:11:47 2008
