1bn0: Difference between revisions
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'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES''' | {{Structure | ||
|PDB= 1bn0 |SIZE=350|CAPTION= <scene name='initialview01'>1bn0</scene> | |||
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'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BN0 is a [ | 1BN0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA]. | ||
==Reference== | ==Reference== | ||
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http:// | Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9743628 9743628] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Borer, P N.]] | [[Category: Borer, P N.]] | ||
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[[Category: tetraloop]] | [[Category: tetraloop]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:13:11 2008'' | ||
Revision as of 08:13, 20 March 2008
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SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES
Overview
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
About this Structure
1BN0 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628
Page seeded by OCA on Thu Mar 20 10:13:11 2008
