1bo8: Difference between revisions

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[[Image:1bo8.gif|left|200px]]<br /><applet load="1bo8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1bo8.gif|left|200px]]
caption="1bo8, resolution 2.40&Aring;" />
 
'''THYMIDYLATE SYNTHASE R178T MUTANT'''<br />
{{Structure
|PDB= 1bo8 |SIZE=350|CAPTION= <scene name='initialview01'>1bo8</scene>, resolution 2.40&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> and <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]
|GENE=
}}
 
'''THYMIDYLATE SYNTHASE R178T MUTANT'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1BO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=U:'>U</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO8 OCA].  
1BO8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BO8 OCA].  


==Reference==
==Reference==
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance"., Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM, Biochemistry. 2000 Feb 8;39(5):1011-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10653645 10653645]
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance"., Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM, Biochemistry. 2000 Feb 8;39(5):1011-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10653645 10653645]
[[Category: Lactobacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase (methyltransferase)]]
[[Category: transferase (methyltransferase)]]


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