1bpv: Difference between revisions
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[[Image:1bpv.gif|left|200px]] | [[Image:1bpv.gif|left|200px]] | ||
'''TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES''' | {{Structure | ||
|PDB= 1bpv |SIZE=350|CAPTION= <scene name='initialview01'>1bpv</scene> | |||
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'''TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BPV is a [ | 1BPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPV OCA]. | ||
==Reference== | ==Reference== | ||
The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains., Goll CM, Pastore A, Nilges M, Structure. 1998 Oct 15;6(10):1291-302. PMID:[http:// | The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains., Goll CM, Pastore A, Nilges M, Structure. 1998 Oct 15;6(10):1291-302. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9782056 9782056] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: titin]] | [[Category: titin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:14:09 2008'' | ||
Revision as of 08:14, 20 March 2008
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TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES
Overview
BACKGROUND: Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II). Type I modules are found exclusively in the region of titin localised in the A band, where they are arranged in a super-repeat pattern that correlates with the ultrastructure of the thick filament. No structure of a titin type I module has been reported so far. RESULTS: We have determined the structure of a representative type I module, A71, using nuclear magnetic resonance (NMR) spectroscopy. The structure has the predicted fibronectin type III fold. Titin-specific conserved residues are either located at the putative module-module interfaces or along one side of the protein surface. Several proline residues that contribute to two stretches in a polyproline II helix conformation are solvent-exposed and line up as a continuous ribbon extending over more than two-thirds of the module surface. Homology models of the type I module N-terminal to A71 (A70) and the double module A70-A71 were used to discuss possible intermodule interactions and their role in module-module orientation. CONCLUSIONS: As residues at the module-module interfaces are highly conserved, we speculate that similar interactions govern all of the interfaces between type I modules in titin. This conservation would lead to a regular multiple array of similar surface structures. Such an arrangement would allow arrays of contiguous type I modules to expose multiple proline stretches in a highly regular way and these may act as binding sites for other thick filament proteins.
About this Structure
1BPV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains., Goll CM, Pastore A, Nilges M, Structure. 1998 Oct 15;6(10):1291-302. PMID:9782056
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