1bwa: Difference between revisions

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[[Image:1bwa.gif|left|200px]]<br /><applet load="1bwa" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1bwa.gif|left|200px]]
caption="1bwa, resolution 1.9&Aring;" />
 
'''HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS'''<br />
{{Structure
|PDB= 1bwa |SIZE=350|CAPTION= <scene name='initialview01'>1bwa</scene>, resolution 1.9&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=XV6:[4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE]'>XV6</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1BWA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=XV6:'>XV6</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWA OCA].  
1BWA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWA OCA].  


==Reference==
==Reference==
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities., Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH, Biochemistry. 1998 Oct 27;37(43):15042-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9790666 9790666]
Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities., Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH, Biochemistry. 1998 Oct 27;37(43):15042-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9790666 9790666]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: hiv-1 protease]]
[[Category: hiv-1 protease]]


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