1bzs: Difference between revisions

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[[Image:1bzs.gif|left|200px]]<br /><applet load="1bzs" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1bzs.gif|left|200px]]
caption="1bzs, resolution 1.7&Aring;" />
 
'''CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909'''<br />
{{Structure
|PDB= 1bzs |SIZE=350|CAPTION= <scene name='initialview01'>1bzs</scene>, resolution 1.7&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=BSI:2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC+ACID'>BSI</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1BZS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=BSI:'>BSI</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZS OCA].  
1BZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BZS OCA].  


==Reference==
==Reference==
Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis., Matter H, Schwab W, Barbier D, Billen G, Haase B, Neises B, Schudok M, Thorwart W, Schreuder H, Brachvogel V, Lonze P, Weithmann KU, J Med Chem. 1999 Jun 3;42(11):1908-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10354399 10354399]
Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis., Matter H, Schwab W, Barbier D, Billen G, Haase B, Neises B, Schudok M, Thorwart W, Schreuder H, Brachvogel V, Lonze P, Weithmann KU, J Med Chem. 1999 Jun 3;42(11):1908-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10354399 10354399]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]
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[[Category: metallo proteinase]]
[[Category: metallo proteinase]]


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