1c16: Difference between revisions
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[[Image:1c16.gif|left|200px]] | [[Image:1c16.gif|left|200px]] | ||
'''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22''' | {{Structure | ||
|PDB= 1c16 |SIZE=350|CAPTION= <scene name='initialview01'>1c16</scene>, resolution 3.10Å | |||
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|LIGAND= | |||
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'''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1C16 is a [ | 1C16 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C16 OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold., Wingren C, Crowley MP, Degano M, Chien Y, Wilson IA, Science. 2000 Jan 14;287(5451):310-4. PMID:[http:// | Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold., Wingren C, Crowley MP, Degano M, Chien Y, Wilson IA, Science. 2000 Jan 14;287(5451):310-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10634787 10634787] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: non-classical mhc-like]] | [[Category: non-classical mhc-like]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:18:30 2008'' | ||
Revision as of 08:18, 20 March 2008
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| 1c16, resolution 3.10Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22
Overview
Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.
Disease
Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]
About this Structure
1C16 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold., Wingren C, Crowley MP, Degano M, Chien Y, Wilson IA, Science. 2000 Jan 14;287(5451):310-4. PMID:10634787
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