1c1s: Difference between revisions

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[[Image:1c1s.jpg|left|200px]]<br /><applet load="1c1s" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1c1s.jpg|left|200px]]
caption="1c1s, resolution 1.63&Aring;" />
 
'''RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES'''<br />
{{Structure
|PDB= 1c1s |SIZE=350|CAPTION= <scene name='initialview01'>1c1s</scene>, resolution 1.63&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=BAB:BIS(5-AMIDINO-BENZIMIDAZOLYL)METHANE'>BAB</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4]
|GENE=
}}
 
'''RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1C1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=BAB:'>BAB</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1S OCA].  
1C1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1S OCA].  


==Reference==
==Reference==
Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases., Katz BA, Luong C, J Mol Biol. 1999 Sep 24;292(3):669-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10497030 10497030]
Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases., Katz BA, Luong C, J Mol Biol. 1999 Sep 24;292(3):669-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10497030 10497030]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: serine protease/inhibitor]]
[[Category: serine protease/inhibitor]]
[[Category: zn(ii) affinity stucture-based drug design]]
[[Category: zn(ii) affinity stucture-based drug design]]
[[Category: zn(ii)-mediated serine protease inhibitors]]
[[Category: zn(ii)-mediated serine protease inhibitor]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:01:31 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:18:51 2008''
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