1c5i: Difference between revisions

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[[Image:1c5i.gif|left|200px]]<br /><applet load="1c5i" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1c5i.gif|left|200px]]
caption="1c5i, resolution 1.8&Aring;" />
 
'''HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF A GLYCOSIDASE'''<br />
{{Structure
|PDB= 1c5i |SIZE=350|CAPTION= <scene name='initialview01'>1c5i</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene> and <scene name='pdbligand=DFX:1,2-DEOXY-2-FLUORO-XYLOPYRANOSE'>DFX</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8]
|GENE=
}}
 
'''HYDROGEN BONDING AND CATALYSIS: AN UNEXPECTED EXPLANATION FOR HOW A SINGLE AMINO ACID SUBSTITUTION CAN CHANGE THE PH OPTIMUM OF A GLYCOSIDASE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1C5I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans] with <scene name='pdbligand=XYP:'>XYP</scene> and <scene name='pdbligand=DFX:'>DFX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5I OCA].  
1C5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5I OCA].  


==Reference==
==Reference==
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase., Joshi MD, Sidhu G, Pot I, Brayer GD, Withers SG, McIntosh LP, J Mol Biol. 2000 May 26;299(1):255-79. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10860737 10860737]
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase., Joshi MD, Sidhu G, Pot I, Brayer GD, Withers SG, McIntosh LP, J Mol Biol. 2000 May 26;299(1):255-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10860737 10860737]
[[Category: Bacillus circulans]]
[[Category: Bacillus circulans]]
[[Category: Endo-1,4-beta-xylanase]]
[[Category: Endo-1,4-beta-xylanase]]
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[[Category: nmr]]
[[Category: nmr]]
[[Category: ph-dependent enzyme mechanism]]
[[Category: ph-dependent enzyme mechanism]]
[[Category: short hydrogen bonds]]
[[Category: short hydrogen bond]]
[[Category: x-ray crystallography]]
[[Category: x-ray crystallography]]
[[Category: xylan]]
[[Category: xylan]]


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