1c8l: Difference between revisions

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[[Image:1c8l.gif|left|200px]]<br /><applet load="1c8l" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1c8l.gif|left|200px]]
caption="1c8l, resolution 2.30&Aring;" />
 
'''SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE'''<br />
{{Structure
|PDB= 1c8l |SIZE=350|CAPTION= <scene name='initialview01'>1c8l</scene>, resolution 2.30&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=BIN:2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM'>BIN</scene>, <scene name='pdbligand=CFF:CAFFEINE'>CFF</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1]
|GENE=
}}
 
'''SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1C8L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=PLP:'>PLP</scene>, <scene name='pdbligand=BIN:'>BIN</scene>, <scene name='pdbligand=CFF:'>CFF</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8L OCA].  
1C8L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8L OCA].  


==Reference==
==Reference==
Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug., Tsitsanou KE, Skamnaki VT, Oikonomakos NG, Arch Biochem Biophys. 2000 Dec 15;384(2):245-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11368311 11368311]
Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug., Tsitsanou KE, Skamnaki VT, Oikonomakos NG, Arch Biochem Biophys. 2000 Dec 15;384(2):245-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11368311 11368311]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Phosphorylase]]
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[[Category: glycogen metabolism]]
[[Category: glycogen metabolism]]
[[Category: inhibitor site]]
[[Category: inhibitor site]]
[[Category: phosphorylase a]]
[[Category: phosphorylase some]]
[[Category: synergistic inhibition]]
[[Category: synergistic inhibition]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:21:15 2008''
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