1c8z: Difference between revisions
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[[Image:1c8z.gif|left|200px]] | [[Image:1c8z.gif|left|200px]] | ||
'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN''' | {{Structure | ||
|PDB= 1c8z |SIZE=350|CAPTION= <scene name='initialview01'>1c8z</scene>, resolution 1.9Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1C8Z is a [ | 1C8Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8Z OCA]. | ||
==Reference== | ==Reference== | ||
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:[http:// | Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10591637 10591637] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: tubby filled-barrel]] | [[Category: tubby filled-barrel]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:21:24 2008'' | ||
Revision as of 08:21, 20 March 2008
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| 1c8z, resolution 1.9Å | |||||||||||||
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| Ligands: | PO4 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN
Overview
Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
About this Structure
1C8Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637
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