1cmi: Difference between revisions
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[[Image:1cmi.gif|left|200px]] | [[Image:1cmi.gif|left|200px]] | ||
'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | {{Structure | ||
|PDB= 1cmi |SIZE=350|CAPTION= <scene name='initialview01'>1cmi</scene>, resolution 2.5Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1CMI is a [ | 1CMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http:// | Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10426949 10426949] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: dynein light chain]] | [[Category: dynein light chain]] | ||
[[Category: lc8]] | [[Category: lc8]] | ||
[[Category: | [[Category: nno]] | ||
[[Category: pin]] | [[Category: pin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:12 2008'' | ||
Revision as of 08:26, 20 March 2008
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| 1cmi, resolution 2.5Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE
Overview
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
Disease
Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]
About this Structure
1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.
Reference
Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949
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