1cq3: Difference between revisions
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'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS''' | {{Structure | ||
|PDB= 1cq3 |SIZE=350|CAPTION= <scene name='initialview01'>1cq3</scene>, resolution 1.85Å | |||
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'''STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1CQ3 is a [ | 1CQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cupixi_virus Cupixi virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CQ3 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:[http:// | Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10535930 10535930] | ||
[[Category: Cupixi virus]] | [[Category: Cupixi virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: chemokine]] | [[Category: chemokine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:27:28 2008'' | ||
Revision as of 08:27, 20 March 2008
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| 1cq3, resolution 1.85Å | |||||||||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF A SOLUBLE SECRETED CHEMOKINE INHIBITOR, VCCI, FROM COWPOX VIRUS
Overview
Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such proteins or derivatives may have therapeutic uses as anti-inflammatory agents. We have determined the crystal structure to 1.85-A resolution of vCCI from cowpox virus, the prototype of this poxvirus virulence factor. The molecule is a beta-sandwich of topology not previously described. A patch of conserved residues on the exposed face of a beta-sheet that is strongly negatively charged might have a role in binding of CC-chemokines, which are positively charged.
About this Structure
1CQ3 is a Single protein structure of sequence from Cupixi virus. Full crystallographic information is available from OCA.
Reference
Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus., Carfi A, Smith CA, Smolak PJ, McGrew J, Wiley DC, Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12379-83. PMID:10535930
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