1cw1: Difference between revisions

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[[Image:1cw1.jpg|left|200px]]~~<br /><applet load~~="1cw1~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1cw1.jpg|left|200px]]

~~caption="~~1cw1, resolution 2.10Å" />

'''CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2+'''~~<br />~~

{{Structure

|PDB= 1cw1 |SIZE=350|CAPTION= <scene name='initialview01'>1cw1</scene>, resolution 2.10Å

|SITE=

|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ICT:ISOCITRIC ACID'>ICT</scene>

|ACTIVITY= [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42]

|GENE=

}}

'''CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2+'''

==Overview==

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==About this Structure==

1CW1 is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] ~~with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ICT:'>ICT</scene> as [http://en.wikipedia~~.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW1 OCA].

1CW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW1 OCA].

==Reference==

Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase., Cherbavaz DB, Lee ME, Stroud RM, Koshland DE Jr, J Mol Biol. 2000 Jan 21;295(3):377-85. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~10623532 10623532]

Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase., Cherbavaz DB, Lee ME, Stroud RM, Koshland DE Jr, J Mol Biol. 2000 Jan 21;295(3):377-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623532 10623532]

[[Category: Escherichia coli]]

[[Category: Isocitrate dehydrogenase (NADP(+))]]

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[[Category: oxidoreductase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu ~~Feb 21 12~~:10:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:29:38 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1cw1.jpg|left|200px]]<br /><applet load="1cw1" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cw1.jpg|left|200px]]
-caption="1cw1, resolution 2.10&Aring;" />
-'''CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2+'''<br />
+ {{Structure
+|PDB= 1cw1 |SIZE=350|CAPTION= <scene name='initialview01'>1cw1</scene>, resolution 2.10&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=ICT:ISOCITRIC ACID'>ICT</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42]
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF ISOCITRATE DEHYDROGENASE MUTANT K230M BOUND TO ISOCITRATE AND MN2+'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-CW1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=ICT:'>ICT</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW1 OCA].
+CW1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CW1 OCA].
 ==Reference==
-Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase., Cherbavaz DB, Lee ME, Stroud RM, Koshland DE Jr, J Mol Biol. 2000 Jan 21;295(3):377-85. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10623532 10623532]
+Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase., Cherbavaz DB, Lee ME, Stroud RM, Koshland DE Jr, J Mol Biol. 2000 Jan 21;295(3):377-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623532 10623532]
 [[Category: Escherichia coli]]
 [[Category: Isocitrate dehydrogenase (NADP(+))]]
@@ Line 23: / Line 32: @@
 [[Category: oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:10:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:29:38 2008''