1d1y: Difference between revisions

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[[Image:1d1y.gif|left|200px]]<br /><applet load="1d1y" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1d1y.gif|left|200px]]
caption="1d1y, resolution 2.20&Aring;" />
 
'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE)'''<br />
{{Structure
|PDB= 1d1y |SIZE=350|CAPTION= <scene name='initialview01'>1d1y</scene>, resolution 2.20&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=3BT:2-{2-[3-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ETHYL}-ISOTHIOUREA'>3BT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=CAD:CACODYLIC+ACID'>CAD</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39]
|GENE=
}}
 
'''BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1D1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=3BT:'>3BT</scene>, <scene name='pdbligand=EDO:'>EDO</scene>, <scene name='pdbligand=CAD:'>CAD</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1Y OCA].  
1D1Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D1Y OCA].  


==Reference==
==Reference==
Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase., Raman CS, Li H, Martasek P, Babu BR, Griffith OW, Masters BS, Poulos TL, J Biol Chem. 2001 Jul 13;276(28):26486-91. Epub 2001 Apr 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11331290 11331290]
Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase., Raman CS, Li H, Martasek P, Babu BR, Griffith OW, Masters BS, Poulos TL, J Biol Chem. 2001 Jul 13;276(28):26486-91. Epub 2001 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11331290 11331290]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Nitric-oxide synthase]]
[[Category: Nitric-oxide synthase]]
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[[Category: oxidoreductase]]
[[Category: oxidoreductase]]


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