1d3u: Difference between revisions
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'''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI''' | {{Structure | ||
|PDB= 1d3u |SIZE=350|CAPTION= <scene name='initialview01'>1d3u</scene>, resolution 2.4Å | |||
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'''TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1D3U is a [ | 1D3U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pyrococcus_woesei Pyrococcus woesei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3U OCA]. | ||
==Reference== | ==Reference== | ||
The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:[http:// | The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10570130 10570130] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Pyrococcus woesei]] | [[Category: Pyrococcus woesei]] | ||
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[[Category: transcription]] | [[Category: transcription]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:32:31 2008'' | ||
Revision as of 08:32, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
TATA-BINDING PROTEIN/TRANSCRIPTION FACTOR (II)B/BRE+TATA-BOX COMPLEX FROM PYROCOCCUS WOESEI
Overview
Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a sequence-specific manner. Here we present the 2.4-A crystal structure of archaeal TBP and the C-terminal core of TFB (TFB(c)) in a complex with an extended TATA-box-containing promoter that provides a detailed picture of the stereospecific interactions between the BRE and a helix-turn-helix motif in the C-terminal cyclin repeat of TFB(c). This interaction is important in determining the level of basal transcription and explicitly defines the direction of transcription.
About this Structure
1D3U is a Protein complex structure of sequences from Pyrococcus woesei. Full crystallographic information is available from OCA.
Reference
The structural basis for the oriented assembly of a TBP/TFB/promoter complex., Littlefield O, Korkhin Y, Sigler PB, Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13668-73. PMID:10570130
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