1dis: Difference between revisions

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[[Image:1dis.gif|left|200px]]<br /><applet load="1dis" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1dis.gif|left|200px]]
caption="1dis" />
 
'''DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE'''<br />
{{Structure
|PDB= 1dis |SIZE=350|CAPTION= <scene name='initialview01'>1dis</scene>
|SITE=  
|LIGAND= <scene name='pdbligand=BDM:BRODIMOPRIM-4,6-DICARBOXYLATE'>BDM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3]
|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1582 Lactobacillus casei])
}}
 
'''DIHYDROFOLATE REDUCTASE (E.C.1.5.1.3) COMPLEX WITH BRODIMOPRIM-4,6-DICARBOXYLATE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1DIS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with <scene name='pdbligand=BDM:'>BDM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIS OCA].  
1DIS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DIS OCA].  


==Reference==
==Reference==
Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase., Morgan WD, Birdsall B, Polshakov VI, Sali D, Kompis I, Feeney J, Biochemistry. 1995 Sep 19;34(37):11690-702. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7547901 7547901]
Solution structure of a brodimoprim analogue in its complex with Lactobacillus casei dihydrofolate reductase., Morgan WD, Birdsall B, Polshakov VI, Sali D, Kompis I, Feeney J, Biochemistry. 1995 Sep 19;34(37):11690-702. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7547901 7547901]
[[Category: Dihydrofolate reductase]]
[[Category: Dihydrofolate reductase]]
[[Category: Lactobacillus casei]]
[[Category: Lactobacillus casei]]
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[[Category: inhibitor/enzyme complex]]
[[Category: inhibitor/enzyme complex]]


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