1yrs: Difference between revisions

Revision as of 12:08, 26 July 2012

Ligands:

ADP, L47, MG

Gene:

KIF11, EG5, KNSL1 (Homo sapiens)

Structural annotation:
Resources:	CATH : 1Yrsa00, 1Yrsb00 InterPro : Ipr001752 Pfam : PF00225 UniProt : P52732

Functional annotation:
Cellular component:	spindle microtubule kinesin complex microtubule spindle pole microtubule associated complex spindle
Biological process:	spindle pole body organization and biogenesis mitosis mitotic spindle organization and biogenesis mitotic centrosome separation microtubule-based movement cell division cell cycle
Molecular function:	motor activity nucleotide binding ATP binding microtubule motor activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1yrs is a 2 chain structure of Kinesin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. PMID:15808464 doi:10.1016/j.bmcl.2005.02.055

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