1e8x: Difference between revisions

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[[Image:1e8x.gif|left|200px]]<br /><applet load="1e8x" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1e8x.gif|left|200px]]
caption="1e8x, resolution 2.2&Aring;" />
 
'''STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING'''<br />
{{Structure
|PDB= 1e8x |SIZE=350|CAPTION= <scene name='initialview01'>1e8x</scene>, resolution 2.2&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=LU:LUTETIUM+(III)+ION'>LU</scene> and <scene name='pdbligand=ATP:ADENOSINE-5'-TRIPHOSPHATE'>ATP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137]
|GENE= P120S144C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 Sus scrofa])
}}
 
'''STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1E8X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=LU:'>LU</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entry 1QMM. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8X OCA].  
1E8X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry 1QMM. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8X OCA].  


==Reference==
==Reference==
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine., Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL, Mol Cell. 2000 Oct;6(4):909-19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11090628 11090628]
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine., Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL, Mol Cell. 2000 Oct;6(4):909-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11090628 11090628]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: secondary messenger generation]]
[[Category: secondary messenger generation]]


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