1e9f: Difference between revisions

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[[Image:1e9f.jpg|left|200px]]<br /><applet load="1e9f" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1e9f.jpg|left|200px]]
caption="1e9f, resolution 1.9&Aring;" />
 
'''MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP'''<br />
{{Structure
|PDB= 1e9f |SIZE=350|CAPTION= <scene name='initialview01'>1e9f</scene>, resolution 1.9&Aring;
|SITE= <scene name='pdbsite=TMP:Adp+Binding+Site'>TMP</scene>
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMP:THYMIDINE-5'-PHOSPHATE'>TMP</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9]
|GENE=
}}
 
'''MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1E9F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=TMP:'>TMP</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] Known structural/functional Site: <scene name='pdbsite=TMP:Adp+Binding+Site'>TMP</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9F OCA].  
1E9F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9F OCA].  


==Reference==
==Reference==
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP., Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I, J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11071809 11071809]
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP., Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I, J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11071809 11071809]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: thymidylate kinase]]
[[Category: thymidylate kinase]]


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