1ea1: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1ea1.jpg|left|200px]]<br /><applet load="1ea1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ea1.jpg|left|200px]]
caption="1ea1, resolution 2.21&Aring;" />
 
'''CYTOCHROME P450 14 ALPHA-STEROL DEMETHYLASE (CYP51) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH FLUCONAZOLE'''<br />
{{Structure
|PDB= 1ea1 |SIZE=350|CAPTION= <scene name='initialview01'>1ea1</scene>, resolution 2.21&Aring;
|SITE= <scene name='pdbsite=HEM:Hem+Binding+Site'>HEM</scene> and <scene name='pdbsite=TPF:Tpf+Binding+Site+Fluconazole+Is+Bound+In+The+Active+Site+...'>TPF</scene>
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene>
|ACTIVITY=
|GENE= CYP51 OR RV0764C OR MTCY369.09C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
}}
 
'''CYTOCHROME P450 14 ALPHA-STEROL DEMETHYLASE (CYP51) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH FLUCONAZOLE'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
1EA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=TPF:'>TPF</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1EA1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Known structural/functional Sites: <scene name='pdbsite=HEM:Hem+Binding+Site'>HEM</scene> and <scene name='pdbsite=TPF:Tpf+Binding+Site+Fluconazole+Is+Bound+In+The+Active+Site+...'>TPF</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EA1 OCA].  
1EA1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. The following page contains interesting information on the relation of 1EA1 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EA1 OCA].  


==Reference==
==Reference==
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors., Podust LM, Poulos TL, Waterman MR, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3068-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11248033 11248033]
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors., Podust LM, Poulos TL, Waterman MR, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3068-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11248033 11248033]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
Line 20: Line 29:
[[Category: TPF]]
[[Category: TPF]]
[[Category: 14 alpha-sterol demethylase]]
[[Category: 14 alpha-sterol demethylase]]
[[Category: azole inhibitors]]
[[Category: azole inhibitor]]
[[Category: cytochrome p450]]
[[Category: cytochrome p450]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:25:31 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:52:22 2008''
Retrieved from "https://proteopedia.org/1ea1"