1ec0: Difference between revisions

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[[Image:1ec0.gif|left|200px]]<br /><applet load="1ec0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ec0.gif|left|200px]]
caption="1ec0, resolution 1.79&Aring;" />
 
'''HIV-1 protease in complex with the inhibitor bea403'''<br />
{{Structure
|PDB= 1ec0 |SIZE=350|CAPTION= <scene name='initialview01'>1ec0</scene>, resolution 1.79&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=BED:N,N-[2,5-O-DI-2-FLUORO-BENZYL-GLUCARYL]-DI-[1-AMINO-INDAN-2-OL]'>BED</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE=
}}
 
'''HIV-1 protease in complex with the inhibitor bea403'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1EC0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=BED:'>BED</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EC0 OCA].  
1EC0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EC0 OCA].  


==Reference==
==Reference==
Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy., Lindberg J, Pyring D, Lowgren S, Rosenquist A, Zuccarello G, Kvarnstrom I, Zhang H, Vrang L, Classon B, Hallberg A, Samuelsson B, Unge T, Eur J Biochem. 2004 Nov;271(22):4594-602. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15560801 15560801]
Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy., Lindberg J, Pyring D, Lowgren S, Rosenquist A, Zuccarello G, Kvarnstrom I, Zhang H, Vrang L, Classon B, Hallberg A, Samuelsson B, Unge T, Eur J Biochem. 2004 Nov;271(22):4594-602. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15560801 15560801]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]


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