1ep4: Difference between revisions

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[[Image:1ep4.jpg|left|200px]]<br /><applet load="1ep4" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ep4.jpg|left|200px]]
caption="1ep4, resolution 2.5&Aring;" />
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153'''<br />
{{Structure
|PDB= 1ep4 |SIZE=350|CAPTION= <scene name='initialview01'>1ep4</scene>, resolution 2.5&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=S11:5-(3,5-DICHLOROPHENYL)THIO-4-ISOPROPYL-1-(PYRIDIN-4-YL-METHYL)-1H-IMIDAZOL-2-YL-METHYL CARBAMATE'>S11</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1EP4 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=S11:'>S11</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EP4 OCA].  
1EP4 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EP4 OCA].  


==Reference==
==Reference==
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding., Ren J, Nichols C, Bird LE, Fujiwara T, Sugimoto H, Stuart DI, Stammers DK, J Biol Chem. 2000 May 12;275(19):14316-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10799511 10799511]
Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding., Ren J, Nichols C, Bird LE, Fujiwara T, Sugimoto H, Stuart DI, Stammers DK, J Biol Chem. 2000 May 12;275(19):14316-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10799511 10799511]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Suginoto, H.]]
[[Category: Suginoto, H.]]
[[Category: S11]]
[[Category: S11]]
[[Category: aids]]
[[Category: aid]]
[[Category: drug design]]
[[Category: drug design]]
[[Category: hiv-1 reverse transcriptase]]
[[Category: hiv-1 reverse transcriptase]]
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[[Category: s-1153]]
[[Category: s-1153]]


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