2h8h: Difference between revisions

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Revision as of 17:32, 26 July 2012

File:2h8h.png

Template:STRUCTURE 2h8h

Src kinase in complex with a quinazoline inhibitor

Template:ABSTRACT PUBMED 17064066

About this Structure

2h8h is a 1 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A, Otterbein L, Ple PA, Warin N, Costello G. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem. 2006 Nov 2;49(22):6465-88. PMID:17064066 doi:10.1021/jm060434q

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