1fc5: Difference between revisions
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[[Image:1fc5.gif|left|200px]] | [[Image:1fc5.gif|left|200px]] | ||
'''CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN''' | {{Structure | ||
|PDB= 1fc5 |SIZE=350|CAPTION= <scene name='initialview01'>1fc5</scene>, resolution 2.2Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1FC5 is a [ | 1FC5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC5 OCA]. | ||
==Reference== | ==Reference== | ||
The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway., Schrag JD, Huang W, Sivaraman J, Smith C, Plamondon J, Larocque R, Matte A, Cygler M, J Mol Biol. 2001 Jul 6;310(2):419-31. PMID:[http:// | The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway., Schrag JD, Huang W, Sivaraman J, Smith C, Plamondon J, Larocque R, Matte A, Cygler M, J Mol Biol. 2001 Jul 6;310(2):419-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11428898 11428898] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: MG]] | [[Category: MG]] | ||
[[Category: bsgi]] | [[Category: bsgi]] | ||
[[Category: four | [[Category: four module]] | ||
[[Category: molybdopterin]] | [[Category: molybdopterin]] | ||
[[Category: montreal-kingston bacterial structural genomics initiative]] | [[Category: montreal-kingston bacterial structural genomics initiative]] | ||
[[Category: structural | [[Category: structural genomic]] | ||
[[Category: with magnesium]] | [[Category: with magnesium]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:07:13 2008'' | ||
Revision as of 09:07, 20 March 2008
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| 1fc5, resolution 2.2Å | |||||||||||||
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| Ligands: | MG | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN
Overview
MoeA is involved in synthesis of the molybdopterin cofactor, although its function is not yet clearly defined. The three-dimensional structure of the Escherichia coli protein was solved at 2.2 A resolution. The locations of highly conserved residues among the prokaryotic and eukaryotic MoeA homologs identifies a cleft in the dimer interface as the likely functional site. Of the four domains of MoeA, domain 2 displays a novel fold and domains 1 and 4 each have only one known structural homolog. Domain 3, in contrast, is structurally similar to many other proteins. The protein that resembles domain 3 most closely is MogA, another protein required for molybdopterin cofactor synthesis. The overall similarity between MoeA and MogA, and the similarities in a constellation of residues that are strongly conserved in MoeA, suggests that these proteins bind similar ligands or substrates and may have similar functions.
About this Structure
1FC5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The crystal structure of Escherichia coli MoeA, a protein from the molybdopterin synthesis pathway., Schrag JD, Huang W, Sivaraman J, Smith C, Plamondon J, Larocque R, Matte A, Cygler M, J Mol Biol. 2001 Jul 6;310(2):419-31. PMID:11428898
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