2qc8: Difference between revisions

Revision as of 23:08, 26 July 2012

Ligands:

ADP, CL, MN, P3S

Gene:

GLUL, GLNS (Homo sapiens)

Activity:

Glutamate--ammonia ligase, with EC number 6.3.1.2

Related:

2ojw

Structural annotation:
Resources:	InterPro : Ipr014746, Ipr008147, Ipr008146 Pfam : PF00120, PF03951 UniProt : P15104

Functional annotation:
Cellular component:	cytoplasm
Biological process:	nitrogen compound metabolic process glutamine biosynthetic process regulation of neurotransmitter levels
Molecular function:	ligase activity glutamate-ammonia ligase activity catalytic activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2qc8 is a 10 chain structure of Glutamine Synthase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Krajewski WW, Collins R, Holmberg-Schiavone L, Jones TA, Karlberg T, Mowbray SL. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design. J Mol Biol. 2008 Jan 4;375(1):217-28. Epub 2007 Oct 17. PMID:18005987 doi:10.1016/j.jmb.2007.10.029

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